WebOur results indicate that MUC1 acts as a modulator of the hypoxic response in pancreatic cancer cells by regulating the expression/stability and activity of hypoxia-inducible factor-1α (HIF-1α). MUC1 physically interacts with HIF-1α and p300 and stabilizes the former at the protein level. By using a ChIP assay, we demonstrate that MUC1 ... WebSep 8, 2024 · Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently. Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME), which have a large impact on tumor …
Three-dimensional core-shell alginate microsphere for cancer hypoxia ...
WebSep 3, 2024 · Hypoxia has been linked to elevated instances of therapeutic resistance in breast cancer. The exposure of proliferating cancer cells to hypoxia has been shown to induce an aggressive phenotype conducive to invasion and metastasis. Regions of the primary tumors in the breast may be exposed to different types of hypoxia including … WebJan 20, 2024 · The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment Strategies to re-engineer … dia of #7 rebar
The role of hypoxia on prostate cancer progression and metastasis
WebApr 14, 2024 · Hypoxia in tumors has been coined as the increase in oxygen demand due to growing vascularization in cancer cells which paves the way to elevated nutrients … WebFeb 28, 2024 · Hypoxia exists to some degree in most solid tumors due to inadequate oxygen delivery of the abnormal vasculature which cannot meet the demands of the … WebDec 9, 2024 · Our studies show that exposure of breast cancer cells to hypoxia induces NARF mRNA and protein expression as a result of direct binding of HIF-1 to the NARF gene promoter. Exposure of breast cancer cells to hypoxia enriches the BCSC population, and knockdown (KD) of NARF abrogates this effect. Consistent with these findings, NARF … dia of #5 rebar