Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are a novel class of drugs that act by inhibiting hypoxia-inducible factor-proline dioxygenase (HIF prolyl-hydroxylase) which is responsible for breaking down the hypoxia-inducible factor (HIF) … WebHIF Prolyl Hydroxylase Inhibitor. Empirical Formula (Hill Notation): C 21 H 16 ClN 3 O. CAS Number: 385786-48-1. Molecular Weight: 361.82. Recommended Products. Slide 1 …
HIF Prolyl Hydroxylase Inhibitor
Web29 de out. de 2024 · Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor is a recently introduced oral agent to treat renal anemia, but its clinical implications on renal functioning in patients with heart failure remains unknown. We studied an 81-year-old man with heart failure with mildly reduced ejection fraction, chronic kidney disease, and renal … Web15 de jan. de 2024 · Adaptaquin, 7-{(4-chlorophenyl)[(3-hydroxypyridin-2-yl)amino]methyl}quinolin-8-ol (1), was identified in our earlier study as a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor by high-throughput screening of cell lines, which stably express the reporter construct encoding a fusion protein composed of the HIF … daluth extra 20% off sale
Efficacy and safety of HIF prolyl-hydroxylase inhibitor vs epoetin …
WebHIF prolyl-hydroxylase has been targeted by a variety of inhibitors that aim to treat stroke, kidney disease, ischemia, anemia, and other important diseases. Clinically observed … Web16 de mar. de 2024 · For NDD-CKD patients, HIF-PHIs could ameliorate functional iron deficiency by promoting iron transport and utilization, which may be achieved by decreasing hepcidin levels. Objective To compare the effects of five hypoxia-inducible factor-prolyl hydroxylase domain inhibitors (HIF-PHIs), two erythropoiesis-stimulating agents … Web15 de jan. de 2009 · DOI: 10.1016/j.ab.2008.09.052 Corpus ID: 2762105; Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence … bird es1 scooter