Thinker trial hcv
WebThe goal of the THINKER-NEXT study is to make more kidneys available for transplant. THINKER-NEXT is a study that will provide HCV infected kidneys to people on the kidney … WebMar 8, 2024 · When the THINKER and EXPANDER trials launched, there was limited utilization of kidneys from HCV-infected donors; therefore, these centers (and others) could be selective. As a result, they largely used kidneys from younger donors with few medical co-morbidities and were predominantly DBD donors.
Thinker trial hcv
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WebSep 4, 2024 · Preliminary data from 2 small trials, including THINKER-1 (Transplanting Hepatitis C kidneys Into Negative KidnEy Recipients), suggested that HCV-infected … WebSep 14, 2024 · , THINKER Trial Investigators Affiliation 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA [email protected]. PMID: …
WebJul 15, 2024 · Two recent, small clinical trials have assessed the feasibility of transplantation of kidneys from HCV-infected donors to HCV-negative recipients. 11-13 The Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients (THINKER) study was an open-label, nonrandomized trial that included 20 HCV–negative recipients who received … WebSep 1, 2024 · The Thinker Trial, a small pilot study by Goldberg, et al. 1 is a pioneering work, but its application remains firmly rooted in the experimental realm. The investigators allocated 10 renal allografts from Hepatitis C (HCV) viremic donors to HCV uninfected recipients and promptly treated them with a 12 week regimen of Elbasvir- Grazoprevir.
WebIn the Transplanting Hepatitis C Kidneys into Negative Kidney Recipients (THINKER) trial, Reese et al 9 reported 1-year outcomes of 10 uninfected patients who received dHCV+ kidneys followed by elbasvir–grazoprevir DAA therapy at the onset of viremia, and 10 additional patients. All patients achieved SVR with excellent kidney function (mean ... WebMay 6, 2024 · The trial is being led at Vanderbilt by David Shaffer, M.D., a professor of surgery in the Division of Kidney and Pancreas Transplantation. In a follow-up to the …
WebJan 4, 2024 · Called THINKER, the next phase of this trial will aim to provide a comprehensive view of the risks and benefits of the practice. It will be led by nephrologist …
WebNov 6, 2024 · HCV Therapy is Not Universally Accessible or Affordable Both clinical trials chose a 12-week regimen including elbasvir-grazoprevir, which has a listing price of $54,600. Patients were enrolled through two distinct investigator-initiated grants, so the cost of therapy was covered by the research protocol. overseas 2300vWebA recent trial evaluated the use glecaprevir/pibrentasvir combined with ezetimibe 10 mg (as an inhibitor of HCV entry) in 30 recipients of nonhepatic organs (lung, heart, kidney) from … overseas 1hrWebSubsequently, all 20 HCV-negative transplant recipients who received kidneys in the THINKER trial met the primary outcome of treatment cure . All of these participants in the THINKER trial received kidneys infected with genotype 1 HCV and were treated with 12–16 weeks of elbasvir-grazoprevir (the duration of therapy being based on the ... ram stuti ringtone downloadWebJan 5, 2024 · THINKER TRIAL • Transplanting Hepatitis C Kidneys into Negative Kidney Recipients • Kidneys from HCV genotype 1–viraemic donors into 10 HCV-negative … rams tumbler cupWebAmong 44 HCV-negative patients listed for organ transplant who were approached for enrollment in the applicable clinical trial, 3 approaches to decision-making emerged: positivist, risk analyses, and instinctual response. Perceptions of risk contributed to conceptualizations of factors influencing decisions. Moreover, most participants relied ... ram stuti lyrics englishWebJan 10, 2024 · January 10, 2024 The next stage of the THINKER project — THINKER-NEXT — is aiming to settle any lingering concerns that patients and centers might have about … rams twilight trail runWebMar 1, 2024 · In another study, called the THINKER trial, 10 HCV-negative patients received kidneys from HCV-viremic donors; all recipients were viremic by post-transplant day 3, and all had HCV genotype 1 (selected based on pre-transplant testing) and no detected resistance-associated substitutions that might limit treatment efficacy . All recipients … overseas 2021